A DHT blocker is a substance that partially inhibits 5-alpha-reductase, the enzyme that converts testosterone into dihydrotestosterone. By reducing the amount of DHT around the follicle, it slows down the miniaturization responsible for hormonal hair loss.
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DHT, the hormone responsible for androgenetic alopecia
Dihydrotestosterone is produced from testosterone by the enzyme 5-alpha-reductase. In genetically predisposed individuals, it binds to receptors in the hair follicle and triggers a well-defined cascade.
- The follicle shrinks — this is follicular miniaturization
- The growth phase shortens with each cycle
- The hair grows back thinner and shorter, then stops growing back altogether.
This mechanism explains male pattern baldness and female androgenetic alopecia, two expressions of the same cause.
Many people believe their hair falls out because it's weakened. In hormonal hair loss, this isn't the case: the hair isn't damaged; it's produced in increasingly smaller hairs by a follicle that DHT shrinks with each cycle. That's why acting early makes all the difference—protecting a follicle is much easier than trying to revive it.
How does a DHT blocker work?
It acts upstream in the cascade, on the enzyme itself. By partially inhibiting 5-alpha-reductase, it reduces the conversion of testosterone to DHT and decreases the hormonal pressure exerted on the follicle. In practical terms, this slows down miniaturization, preserves the remaining active follicles, and allows the hair cycle time to unfold normally.
Two limitations must be kept in mind. Inhibition is never total, even with medication. And the effect lasts as long as the medication is taken: once stopped, conversion resumes.
Which assets actually block DHT?
Several ingredients are presented as natural blockers, with very uneven levels of evidence:
- Saw palmetto (Serenoa repens) — the best-documented natural active ingredient, the only one to have been evaluated in a comparative trial against finasteride
- Pumpkin seed oil — has a randomized, placebo-controlled trial on androgenetic alopecia
- Zinc and vitamins B6 and B8 — cofactors of keratin synthesis, without a significant direct inhibitory effect
- Green tea and pygeum — evaluated in the laboratory only, without human data
- Finasteride and dutasteride — synthetic inhibitors, available by prescription, which are significantly more potent
The decisive point is not the name of the active ingredient but its form: a standardized extract, whose concentration is announced, and not a powder of simply ground plant.
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Discover the solutionThings to check before choosing a DHT blocker
The amount of active ingredients actually delivered is the only figure that allows for a direct comparison between two formulas, and almost no brand displays this information. Our DHT Blocker® is based on 300 mg of standardized Serenoa repens extract standardized to 45% fatty acids, which translates to 135 mg of fatty acids per daily dose and the equivalent of 1,200 mg of the plant. It is combined with 2 million CFU of Lactobacillus acidophilus PBS066, green tea, ginseng, zinc, and vitamins B6, B8, and D3—active ingredients with French certifications, manufactured in France to pharmaceutical standards.
Allow at least three months, the duration of a hair cycle, and be aware that a supplement alone only covers one of the four mechanisms of hormonal hair loss.
Hormonal Anti-Hair Loss Protocol
Specifically acts on hormonal hair loss
To remember
- A DHT blocker acts on the enzyme, not on the hair.
- Saw palmetto is the only natural active ingredient evaluated against finasteride.
- It is the standardized extract that works, not the plant powder.
- When the hormonal conversion stops, it resumes its course.
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