The 5 factors of hair loss, and how to act from within

What you must remember

Hair loss depends on five factors: nutritional, vascular, tissue, hormonal, and nervous. A supplement addresses these factors—providing sulfur-containing amino acids, promoting collagen synthesis, and improving blood flow—but its hormonal effect remains limited. Allow three months, the duration of a menstrual cycle.

  • Five factors are involved in hair loss: nutritional, vascular, tissue, hormonal, and nervous.
  • Sulfur-containing amino acids provide the sulfur for keratin bonds
  • The effect of a supplement on hormones remains limited
  • A minimum of three months: that's the duration of a hair cycle.
anti-hair loss food supplement

Hair loss is never caused by a single factor. Five factors are involved—nutritional, vascular, tissue, hormonal, and nervous—and a treatment only works if it addresses them all. Here's what each factor encompasses, and what a supplement can actually provide.

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What are the 5 factors of hair loss?

Hair is a direct indicator of overall physiological state. Its quality depends on five factors, the importance of which varies from person to person and depending on the type of hair loss.

  • The nutritional factor: sulfur amino acids and cofactors necessary for keratin synthesis
  • The vascular factor: the microcirculation that supplies the follicle
  • The tissue factor: the quality of the collagen that anchors the hair in the scalp
  • The hormonal factor: DHT, the main driver of androgenic alopecia
  • The nervous factor: the effect of chronic stress on the hair cycle


A dietary supplement works on the body's internal environment, not on hormones. Zinc and B vitamins play a role, but their hormonal effect remains limited—and I prefer to be clear about that. For an established hormonal imbalance, they are a useful support, not the primary treatment.
Dr. Julie PernetDoctor of Pharmacy & Certified Trichologist

How does a supplement affect these factors?

Two sulfur-containing amino acids, methionine and cystine, provide the sulfur necessary for the bonds that structure keratin—the very bonds that give hair its strength. Glycine and vitamin C play a role in collagen synthesis, which anchors the hair. Zinc and biotin complete the formula, and plant extracts support scalp blood flow.

On which falls is a supplement relevant?

Nutritional intake is of real importance in several situations:

  • A reactive fallwhere many follicles restart at the same time
  • A postpartum fall, outside of the breastfeeding period
  • A seasonal autumn fall, to support regrowth
  • An unbalanced diet or a restrictive diet
  • Hair that grows back thin and brittle, rather than falling out

In the case of an established hormonal decline, the supplement provides support: the action on DHT remains the main lever.

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I tried the serum, thinking it wouldn't work... and yet! The bald spot on the back of my head has clearly filled in. Amazing!

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How long does it take to see results?

The hair growth cycle dictates its own schedule. Hair grows approximately 0,2 mm per day: the portion produced during the treatment emerges stronger from the first few weeks, but it takes three months for this to be noticeable. This is why a treatment is measured in months, not weeks, and why it reaches its full potential when combined with topical action—serum, massage, microcirculation.

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To remember

  • Five factors are involved in hair loss: nutritional, vascular, tissue, hormonal, and nervous.
  • Sulfur-containing amino acids provide the sulfur for keratin bonds
  • The effect of a supplement on hormones remains limited
  • A minimum of three months: that's the duration of a hair cycle.

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F.A.Q

What are the 5 factors of hair loss?
The nutritional factor, the vascular factor, the tissue factor, the hormonal factor, and the nervous factor. Their relative importance varies from person to person: a reactive hair loss primarily involves the first three, a hormonal hair loss the fourth.
Does a dietary supplement have an effect on hormonal decline?
Only partially. Zinc and B vitamins play a role in hormonal balance, but their effect remains limited. In cases of androgenic alopecia, a supplement supports the body's natural processes without replacing targeted action on the conversion of testosterone to DHT.
How long does it take for an anti-hair loss supplement to take effect?
Allow three months, the duration of a hair growth cycle. The portion of hair produced during the treatment is stronger from the first weeks, but it takes several months to become visible, at a rate of about one centimeter per month.
Should you take your anti-hair loss supplement during or between meals?
Drink with a glass of water during meals. An empty stomach is more sensitive, and many nutrients are better absorbed in the presence of food. This also reduces the risk of digestive discomfort.
Is an anti-hair loss supplement sufficient on its own?
No, it acts from within on the nutritional level. The microcirculation of the scalp and the condition of the root require local action: it is the combination of the two, maintained for several months, that produces a visible result.

Written by

Dr. Julie Pernet

Doctor of Pharmacy & Certified Trichologist. Doctor of Pharmacy and Trichologist, founder of the DermoPilaire MakeMyMask Laboratory. She develops skincare protocols focused on scalp health, based on microbiome science and pH balance.

Dr. Julie Pernet