DHT Blocker: Which is the best DHT blocker on the market according to science?

What you must remember

Not all DHT blockers are created equal. It's not the milligrams of saw palmetto that are effective, but the fatty acids in the standardized extract. Our formula delivers 96 mg of active fatty acids from 300 mg of concentrated extract, combined with probiotics and cofactors that ensure absorption and effectiveness.

  • It is the fatty acids in the extract that are active, not the milligrams of plant material.
  • Our formula delivers 96 mg of active fatty acids per 300 mg of concentrated extract
  • Probiotics influence the actual absorption of active ingredients
  • A minimum of three months: that's the duration of a complete hair cycle.
DHT Blocker: Which is the best DHT blocker on the market according to science?

DHT is now recognized as one of the main biological factors in androgenetic alopecia, in both men and women. In response, many supplements claim to be "DHT blockers"—but they are far from all being created equal. The real question isn't "Does it contain saw palmetto?", but "How many active fatty acids actually reach the body?"

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What exactly is a DHT blocker?

A DHT blocker is a substance capable of reducing the activity of 5-alpha-reductase, the enzyme that converts testosterone into DHT. This hormone shortens the hair growth phase, progressively miniaturizes the follicle, and leads to its thinning and eventual disappearance. Partially inhibiting this enzyme slows down the androgenic mechanism without disrupting the overall hormonal balance.

  • It acts on the hormonal cause, not on the symptom
  • It hinders miniaturization rather than stimulating growth
  • Its effect is gradual and lasts as long as it is taken regularly.


What few brands mention is that not all Saw Palmetto extracts are created equal. Two capsules with the same number of milligrams can have completely different enzymatic activities. The only number that matters is the actual amount of active fatty acids delivered.
Dr. Julie PernetDoctor of Pharmacy & Certified Trichologist

Saw Palmetto: the benchmark active ingredient, provided it is properly extracted

Saw palmetto is the most studied natural active ingredient for its effect on 5-alpha-reductase. However, it's not the milligrams of the plant itself that are effective: it's the fatty acids contained in the extract. Raw berry powder, no matter how concentrated, doesn't provide these compounds in sufficient quantities—without fatty acid standardization, saw palmetto is biologically ineffective.

How to recognize a DHT blocker that is actually dosed

Before buying, check these points on the label:

  • The mention of a standardized extract, and not a berry powder
  • The fresh plant equivalent, which indicates the degree of concentration
  • The amount of active fatty acids delivered per day, expressed in milligrams
  • The presence of metabolic cofactors: zinc, vitamins B6, B8 and D3
  • An absorption system, with probiotics improving the bioavailability of active ingredients
  • A treatment period of at least three months, aligned with the hair cycle

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The best DHT blocker: a matter of science, not marketing

The best DHT blocker isn't necessarily the one with the highest milligram count on the label, but rather the one that actually delivers the active fatty acids to the target area, along with the cofactors that support keratin synthesis and microcirculation. This formulation requirement is what separates a supplement from a true skincare tool—and it's also why a DHT blocker delivers its full potential when used as part of a comprehensive skincare protocol.

Hormonal Anti-Hair Loss Protocol

Specifically acts on hormonal hair loss

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To remember

  • It is the fatty acids in the extract that are active, not the milligrams of plant material.
  • Our formula delivers 96 mg of active fatty acids per 300 mg of concentrated extract
  • Probiotics influence the actual absorption of active ingredients
  • A minimum of three months: that's the duration of a complete hair cycle.

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F.A.Q

How can you tell if a DHT blocker is properly dosed?
Look for three pieces of information: whether it's a standardized extract or a powder, the plant equivalent, and the amount of active fatty acids delivered. If any of these three are missing, you can't evaluate the product—and their absence is rarely an oversight.
Why include probiotics in an anti-hair loss supplement?
Because poorly absorbed nutrients are wasted nutrients. Probiotics improve the bioavailability of Saw Palmetto and other nutrients in the formula. Since fatty acids and phytosterols are fat-soluble, taking them with a meal further enhances absorption.
How long does it take to see results?
Allow three months, the duration of a complete hair growth cycle. This is why the treatment is packaged in 180 capsules, to be taken two per day. Judging results before this time is physiologically meaningless.
Is the DHT Blocker compatible with a contraceptive pill?
No clinically significant interactions between saw palmetto and oral contraceptives have been reported in the literature. It acts peripherally on the conversion of testosterone to DHT and has no anti-estrogenic effect. In cases of specific hormonal imbalances, medical advice is still recommended.

Written by

Dr. Julie Pernet

Doctor of Pharmacy & Certified Trichologist. Doctor of Pharmacy and Trichologist, founder of the DermoPilaire MakeMyMask Laboratory. She develops skincare protocols focused on scalp health, based on microbiome science and pH balance.

Dr. Julie Pernet